Chronic ureteral obstruction in the rat suppresses renal tubular Bcl-2 and stimulates apoptosis

RL Chevalier, CD Smith, J Wolstenholme… - Experimental …, 2000 - karger.com
… of bax staining in tubules of the obstructed kidney overlapped that of bcl-2. We conclude
that chronic UUO inhibits bcl-2 expression in selected tubules of the obstructed kidney which …

[HTML][HTML] Role of Sirolimus in renal tubular apoptosis in response to unilateral ureteral obstruction

M Yang, Y Zhuang, W Wang, H Zhu… - … Journal of Medical …, 2018 - ncbi.nlm.nih.gov
rats were divided into three groups, sham-operated rats, and … Thus, suppression of apoptosis
signaling has been included … apoptosis Bcl-2 and Bax may play key roles in the process of …

[HTML][HTML] Ulinastatin inhibits renal tubular epithelial apoptosis and interstitial fibrosis in rats with unilateral ureteral obstruction

QF Zhang - Molecular medicine reports, 2017 - spandidos-publications.com
… by lipopolysaccharide (LPS) and severe burns (7). Animal … the renal tissues of renal injury
rats induced by severe burns … Bcl-2 expression decreased in the renal tubular epithelium of …

Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction

NG Docherty, OE O'Sullivan… - … Physiology-Renal …, 2006 - journals.physiology.org
… , reduced tubular apoptosis in the obstructed kidneys of rats … of Bcl-2 localization in the
mitochondria of tubular epithelial … factor suppresses renal tubular apoptosis following ureteral

[HTML][HTML] Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney

SD Chung, TY Lai, CT Chien, HJ Yu - 2012 - journals.plos.org
Bcl-2 augmentation protects renal tubular epithelial cells from oxidative injury by suppressing
both autophagy and apoptosisrats during UUO, resulting in further increased renal tubular

The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: the role of oxidative stress, inflammation and apoptosis

A Kaeidi, A Sahamsizadeh, M Allahtavakoli… - Molecular biology …, 2020 - Springer
… rise in renal tubular pressure [3] and renal vascular … biochemical parameters of apoptosis
(Bax, Bcl-2 and cleaved … Furthermore, oleuropein inhibits oxidative stress and exhibits a …

Erythropoietin attenuates renal injury in an experimental model of rat unilateral ureteral obstruction via anti-inflammatory and anti-apoptotic effects

YK Chang, DE Choi, KR Na, SJ Lee, KS Suh… - The Journal of …, 2009 - auajournals.org
… In our study EPO suppressed the … Tubular production of the anti-apoptotic oncoprotein Bcl-2
is inversely related to the regional apoptosis of renal tubular epithelial cells in the obstructed

Effect of stachydrine on endoplasmic reticulum stress-induced apoptosis in rat kidney after unilateral ureteral obstruction

C Zhang, Y Lu, QQ Tong, L Zhang… - Journal of Asian …, 2013 - Taylor & Francis
… Then UPR was suppressed to block ERS signal transduction … apoptosis by inhibiting Bcl-2
(proteins regulating apoptosis … , which indicated the apoptosis of renal tubular epithelial cells. …

Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway

JH Kim, JI Yang, MH Jung, JS Hwa… - Journal of the …, 2006 - journals.lww.com
… determine whether Bcl-2 was implicated in apoptosis in this … Upregulation of HO-1 inhibits
apoptosis both in vitro ( 26 , 28 ) … that renal tubular apoptosis is related to renal tissue loss and …

Epigallocatechin-3-gallate reduces tubular cell apoptosis in mice with ureteral obstruction

Y Wang, N Liu, X Bian, G Sun, F Du, B Wang… - journal of surgical …, 2015 - Elsevier
… -2 (Bcl-2) was upregulated and protein expressions of Bcl-2 … The role of tubular apoptosis
in the genesis of renal tubular … -β1–induced apoptosis in normal rat kidney proximal tubular